Globally, agriculture exerts an important pressure on water resources. Particularly, the Italian consumption of water resources is due to the agricultural sector and food transformation which consume 70%–80% of the total. Therefore, using the concept of water footprint (WF) theorized in 2002 by Hoekstra and based on the concept of virtual water proposed by Allan in 1993, the authors focused on possible combinate approaches to WF and other tools associated with some important agricultural and food production to present an overview of current water consumption and possible reductions envisaged by Next Generation Programme. Furthermore, starting from a systematic literature analysis of past studies collected and indexed on main scientific platforms (Scopus and Web of Science), the authors highlighted the research needs and the necessary practical implications associated with the combination of WF and geographic information system (GIS). Particularly, the authors are involved in the GRINS (Growing, Resilient, Inclusive and Sustainable) Programme, financed by NextGenerationEU within the Italian recovery and resilience plan. The purpose of the GRINS Programme is the "production of a georeferenced data platform at a very granular level, useful for various applications: basic and applied research on businesses, households, public administration, sustainable finance, innovation, characterization policies, territorial gaps, and social sustainability". Particularly, the authors focused on the WF at the national level for the agricultural sector.